Evaluation of complexity of induced necrosis zone shape by means of principal component analysis

Darijus Skaudickas1 , Vincentas Veikutis2 , Aleksandras Vitkus3 , Greta Peciulyte4 , Dalia Marciulionyte5 , Gintare Sakalyte6 , Algimantas Krisciukaitis7 , Gintautas Vaitiekaitis8

1Lithuanian University of Health Sciences Clinical Hospital, Department of Urology, Kaunas, Lithuania

2Lithuanian University of Health Sciences, Institute of Cardiology, Institute of Microbiology and Virology, Kaunas, Lithuania

3Lithuanian University of Health Sciences, Department of Histology and Embryology, Kaunas, Lithuania

4Lithuanian University of Health Sciences, Medical Academy, Kaunas, Lithuania

5Lithuanian University of Health Sciences, Institute of Microbiology and Virology, Kaunas, Lithuania

6Lithuanian University of Health Sciences Clinical Hospital, Department of Cardiology, Kaunas, Lithuania

7, 8Lithuanian University of Health Sciences, Department of Physics, Mathematics and Biophysics, Kaunas, Lithuania

2Corresponding author

Journal of Vibroengineering, Vol. 16, Issue 8, 2014, p. 4115-4125.
Received 13 October 2014; received in revised form 30 November 2014; accepted 20 December 2014; published 30 December 2014

Copyright © 2014 JVE International Ltd. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract.

Radiofrequency ablation (RFA) is medical procedure that causes coagulation necrosis in the ablative tissue. Experts using descriptive and morphometric methods usually assess the shape of necrosis zone. However, a precise and objective assessment of necrosis zone shape requires quantitative evaluation methodology that includes computerized mathematical algorithms. One of such methods is presented in the program package “SHAPE ver.1.3”, in which quantitative evaluation of various biological contour shapes is based on principal component analysis of elliptic Fourier descriptors (EFDs). Aim of present study was elaboration of quantitative measure for complexity of the necrosis zone shape after radiofrequency ablation. We performed assessment of suitability of computer program package “SHAPE ver. 1.3” to produce valuable estimates of necrosis zone shape. Minimal yet sufficient number of principal components for optimal representation of necrosis area shape could be a quantitative measure of the shape complexity. Program package “SHAPE ver.1.3” together with proposed procedure for determination of this measure could be used for optimization of radiofrequency ablation procedures.

Keywords: quantitative evaluation of shape, radiofrequency ablation, coagulation necrosis, elliptic Fourier descriptors, “SHAPE ver.1.3”.

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