Investigations and evaluations of the complexity of living organisms and their systems. Holistic relationships and synchronization of internal systems (and groups of subsystems) of the organism. The complexity of interrelationships between internal systems of the organism during physical activity and recovery processes. Investigation of the effect of different pathological processes and illnesses to the self-organization of living organisms. The complexity of societal health and wellness. The development of novel technological, mathematical and computational techniques for the assessment of the complexity in general and the holistic interrelationships of different subsystems in a living organism(s) in particular.